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4-Androstene-3,6,17-trione (6-OXO) Description:
Nutritional supplements designed with the intent of inhibiting aromatase activity are relatively new to the fitness community. Examples of these supplements are 6-OXO and Novedex XT, and are alleged to act similar to such aromatase inhibiting drugs as formestane. It was recently shown that eight weeks of supplementation with the aromatase inhibiting nutritional supplement Novedex.
XT (hydroxyandrost-4-ene-6,17-dioxo-3-THP ether and 3,17-diketo-androst-1,4,6-triene) was effective at increasing serum testosterone and DHT, while only displaying slight increases in estrogen levels. Additionally, compounds with the same (androst-4-ene-3,6,17-trione) and very similar (androst-5-ene-4,7,17-trione) structure as 6-OXO have been shown to irreversibly bind to the aromatase enzyme thereby causing a decrease in estradiol production. Therefore, use of these aromatase-inhibiting compounds seem to decrease aromatization and subsequent estradiol synthesis, which apparently increases both TST and T/E.
In regard to body composition, neither dose of 6-OXO demonstrated any significant improvement in fat mass or fat-free mass over the course of the study. Even with significant increases in FT and DHT, this furthers indicates that 6-OXO supplemented at these dosages for eight weeks did not decrease fat mass or cause an anabolic response by increasing muscle mass.
The results of this study indicate that eight weeks of 6-OXO supplementation had no effect on body composition or clinical safety markers, but incompletely inhibited aromatase activity and significantly increased endogenous DHT levels that were attenuated after a three-week washout period. Therefore, while neither of the 6-OXO dosages appears to have any negative effects on clinical chemistry markers, supplementation at a daily dosage of 300 mg and 600 mg for eight weeks did not completely inhibit aromatase activity, yet significantly increased FT, DHT, and T/E.
4-Androstene-3,6,17-trione (6-OXO) Characteristics
6-OXO is a steroidal aromatase inhibitor, known as a suicidal inhibitor because it permanently binds to the aromatase enzyme. It is used for its anti-estrogen and testosterone boosting effects.
There is debate about whether or not 6-oxo actually lowers estrogen or increases testosterone. Several human studies have shown an increase in estrone levels following 6-oxo supplementation. However, one of the primary metabolites of 6-oxo is 6-oxoestrone which may have given a false positive for elevated estrone levels. The human study also concluded that 6-oxo raised testosterone levels, however it is possible that 6-oxotestosterone (which is another metabolite of 6-oxo) gave a false positive for the testosterone level as well.
Another interesting element to these articles is that despite the supposed increase in testosterone (enough to cause significant improvements in body composition if given via injection) no improvements where found for fat free mass (FFM) or strength. Therefore, 6-oxo is either a weak AI that doesn’t really inhibit estrogen at the recommended dose and simply converts to metabolites which give false readings, or it actually does increase testosterone, while the 6-oxo metabolites antagonize the androgen receptor enough to block any anabolic effect from testosterone.
Either way, no ergonomic or real world benefit could be found after 6-oxo supplementation.
Its also worth mentioning that 6-oxo should never be used post cycle, as its steroidial effects would likely interfere with recovery of natural testosterone production.