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Nolvadex Dosage for Increased Endogenous Testosterone Secretion and PCT (Post Cycle Therapy)
The effects of Nolvadex doses on the endogenous production of Testosterone in men is well documented and very profound. This occurs via Nolvadex’s Estrogen antagonistic effects on the hypothalamus and pituitary gland, which results in the significant release of FSH and LH (the two hormones responsible for signaling the testes to begin and/or increase the production and secretion of Testosterone. It is for this reason that Nolvadex, and its close relative compound Clomid, are known as absolutely essential components to a PCT program for the purpose of hormonal recovery following the termination of an anabolic steroid cycle.
Nolvadex has in fact demonstrated to be the far more effective compound at doing this job than the more commonly utilized Clomid, and many anabolic steroid using bodybuilders and athletes are growing increasingly aware of this fact. Although nearly all studies on males demonstrated increases in Testosterone secretion following Nolvadex, there exists one notable study that stands out among all others. This particular study demonstrated that the administration of Nolvadex doses at 20mg daily for 10 days on normal healthy males generated a 150% increase in Testosterone levels, which is the equivalent effect of 150mg of Clomid, as noted by the study. This same study also noted that Clomid actually generated a decreased LH secretion to LH-Releasing Hormone (LHRH) – something that Nolvadex did not do and in fact served to increase the body’s sensitivity to LHRH in the aforementioned study. Between the choice of Nolvadex and Clomid for the purpose of Testosterone stimulation, Nolvadex should be the preferred agent of the two.
Therefore, Nolvadex is the superior choice not only for the purpose of stimulating endogenous Testosterone secretion, but also for mitigating gynecomastia. The standard dose for PCT and for stimulating the release of GnRH (Gonadotropin Releasing Hormone), LH, FSH, and ultimately Testosterone is that of a simple Nolvadex dose of 20 – 40mg daily. In all studies involving Nolvadex doses that stimulated endogenous Testosterone production, only 20 – 40mg daily of Nolvadex was utilized, and it has in fact been shown that doubling the dose to 40mg or any higher will not produce any significant difference in endogenous Testosterone secretion. The only reason why many elect to utilize 40mg daily of Nolvadex for the first 2 weeks of a PCT program is for the purpose of achieving optimal peak blood plasma levels quicker so as to ensure HPTA recovery quicker.
One last note in regards to Nolvadex use during PCT – the aromatase inhibitors Letrozole and Arimidex in combination with Nolvadex will result in a negative drug interaction in which both directly counteract one another. This can occur in the use of Arimidex and Nolvadex together, or Letrozole and Nolvadex together. One study has demonstrated that when Letrozole or Arimidex are utilized with Nolvadex, Nolvadex will decrease blood plasma concentration of Letrozole as well as Arimidex. This problem is not evident in Aromasin (Exemestane). Therefore, if an individual wishes to include the use of an aromatase inhibitor in a PCT protocol, the only ideal AI of choice with Nolvadex should be Aromasin (Exemestane).